Zyprexa e Suicidio: Ora potrebbe essere necessario guardare i vostri bambini

Zyprexa Suicide: Now You May Have to Watch Your Children

October 1, 2007

Rockville, MDIn what may be one of the more astounding moves of the year, a U.S. Food and Drug Administration official has overruled his colleagues and will recommend Zyprexa be approved for the treatment of adolescents diagnosed with mental illness. The move comes despite evidence that Zyprexa has been linked to [Suicides], diabetes, weight gain and pancreatitis.
Initially a three-member FDA team recommended Zyprexa be rejected for use in adolescents because they received inconsistent data from studies conducted on teens in the U.S. and Russia. However, Thomas Laughren, who is the head of the FDA's psychiatry division, has overruled that recommendation.

A study, published in the October 2007 edition of [The American Journal of Psychiatry] has found that Zyprexa effectively treated bipolar mania in adolescent patients. However, the study also found that patients treated with Zyprexa, "had significantly greater weight gain and increases in the levels of hepatic enzymes, prolactin, fasting glucose, fasting total cholesterol, and uric acid." Furthermore, the lead author of the study was Maricio Tohen, a professor of psychiatry at Harvard and an Eli Lilly employee.
Participants who took Zyprexa in the study, which occurred over only three weeks, gained an average of eight pounds. That's eight pounds in only three weeks, an incredibly short time to gain that amount of weight. Three weeks is certainly not long enough to determine what the risk of suicide is in adolescents who take Zyprexa.
Zyprexa had $4.4 billion in global sales in 2006 and is Eli Lilly and Co.'s best-selling drug.

READ MORE LEGAL NEWS

• Long-Acting Zyprexa Gets Limited Ok by FDA
• Zyprexa: Eli Lilly could be Tagged with $1 Billion Dollar Fine
• Zyprexa Suicide: Children at Risk

Exactly what effect the potential approval will have on the suicide rate of teens is not known. After all, Lilly has already been in trouble for promoting Zyprexa for off-label uses and although Zyprexa is not currently approved for use in adolescents, many doctors still prescribe if off-label. This is not illegal, but it certainly is questionable in light of the consequences some adults have faced after taking Zyprexa.
Pre-marketing clinical trials showed that Zyprexa had a higher rate of suicide than any other antipsychotic. According to Zyprexa's label, suicide is an infrequent (but not rare) side effect. Infrequent adverse events occur in between 1/100 and 1/1000 patients. Zyprexa is currently approved to treat symptoms of schizophrenia and acute bipolar mania in adults.
Given all the serious side-effects reported in Zyprexa - weight gain, pancreatitis and risk of suicide to name a few - should we really be giving youth this drug without having a better understanding of how it works? Since Zyprexa has been linked to an increased risk of suicide attempts in adults, shouldn't we understand that risk better before we give it to youth?

Zyprexa Suicide Legal Help - Suicidio Zyprexa Aiuto Legale

Zyprexa, Abilify, Risperdal e Seroquel collegati a Rapido Aumento di Peso nei Bambini

Zyprexa, Abilify, Risperdal, and Seroquel Linked to Rapid Weight Gain in Children

October 29, 2009

Washington, DCThe largest study of its kind to show an association between atypical antipsychotics such as Zyprexa, and rapid weight gain and metabolic changes that can lead to diabetes and hypertension was published Wednesday in the Journal of the American Medical Association (JAMA). The study was conducted in 272 children aged between 4 and 19 years. 

Study investigators evaluated the four top selling antipsychotic medications used in the treatment of schizophrenia and bipolar disorder, namely Zyprexa (Eli Lilly & Co); Abilify, (Bristol-Myers Squibb Co and Otsuka Pharmaceutical Co); Risperdal (Johnson & Johnson); and Seroquel ( AstraZeneca PLC).
Of the four atypical antipsychotics, Zyprexa caused the most weight gain over the course of the study – at nearly 19 lbs, a 15 percent increase. Importantly, Zyprexa was also found to significantly raise cholesterol, insulin, triglycerides and blood sugar levels, all of which can lead to the development of diabetes and heart disease.
Children taking Abilify, Risperdal, and Seroquel gained an average of between 10 and 13 pounds over the 11 weeks, and the drugs' impact on metabolic disease indicators varied.
In an article published in the Wall Street Journal (wsj.com), Christoph Correll, the study's lead author and a psychiatrist and scientist at the Feinstein Institute for Medical Research in Manhasset, NY, said, "The weight gain is much larger than we thought. It's massive, and it's the medication that caused it."

 

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#Zyprexa #Abilify #Risperdal #Seroquel #Obesità #Bambini 

#Diabete #Ipetensione #JAMA #WSJ

Ancora altre cause per Seroquel, un Avvocato stima che difendere Seroquel potrebbe costare 10 Miliardi ad AstraZeneca

Seroquel Lawsuits Add Up

May 21, 2007

Dover, DE

Over 350 lawsuits were filed in Delaware last month against the maker of Seroquel. That is more than has been filed in the state in the past two years, which began against AstraZeneca Pharmaceuticals after the FDA ordered a change in Seroquel's label, to warn users about an increased risk of diabetes.

One lawyer estimates that defending Seroquel could cost its maker $10 billion. According to one report, there were almost 7,100 Seroquel cases in the federal multidistrict litigation (MDL). Additionally, there are 1,291 Seroquel claims in New Jersey. 

Seroquel lawsuitsIn response to concerns about Seroquel, a study is being conducted in Fort Lauderdale, Florida to determine the safety and usefulness of Seroquel in patients with acute bipolar mania. The study will examine both men and women ages 18-65.

Meanwhile, a study conducted by Medco Health Inc., the biggest prescription benefit manager in the U.S., has found that antipsychotic drug use in children has almost doubled. This includes Seroquel, which is approved to treat schizophrenia and bipolar disorder in adults but not in children.

AstraZeneca Pharmaceuticals L.P., is also in trouble for how it marketed the drug. The company disclosed in its 2006 annual report that the Philadelphia U.S. Attorney's Office is investigating "allegations that the company promoted Seroquel of non-indicated (off-label) uses." A warning letter was sent to AstraZeneca's director of promotional regulatory affairs on November 16, 2006. The letter raised the FDA's concerns that AstraZeneca was minimizing the risks associated with Seroquel in its promotional material.

In addition to diabetes, Seroquel has been linked to pancreatitis, an inflammation of the pancreas, hyperglycemia, and Neuroleptic Malignant Syndrome, a potentially fatal syndrome with symptoms that include irregular heartbeat, fever, and stiff muscles. It may also increase the risk of death in seniors who have dementia-related mental problems, a condition that Seroquel has not been approved to treat.

Seroquel, known generically as quetiapine fumarate, is an atypical anti-psychotic drug used to treat symptoms schizophrenia including delusions, hallucinations, social withdrawal, and thought disorder. The drug has also been prescribed to treat acute bipolar mania, severe anxiety, and agitation. The FDA approved Seroquel in 1997.

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#Seroquel #Diabete #Pancreatiti #SNM #AIVN 

AstraZeneca accusata di minimizzare rischio diabete con Seroquel

AstraZeneca Accused of Downplaying Seroquel 
Diabetes Risk

October 8, 2009

Orlando, FL
Defective product personal injury, together with the alleged attempts by Seroquel manufacturer AstraZeneca to downplay concern over diabetes and weight gain, have combined to foster lawsuits by upwards of 15,000 Seroquel patients.
Now, the order by a federal judge in Orlando to unseal sales call notes made by AstraZeneca representatives paints a vivid picture as to how AstraZeneca employees attempted to mitigate concern over diabetes risk involving Seroquel.
According to a Bloomberg News report that appeared September 23rd in the Wilmington, Delaware News Journal, a saleswoman employed by AstraZeneca told a US doctor that Seroquel did not cause diabetes and downplayed the concern. This, four years after AstraZeneca warned physicians in Japan as to Seroquel's links with the disease.
It was in 2002 that AstraZeneca alerted Japanese physicians after the manufacturer received reports of diabetes-related cases tied to Seroquel, "where causality with the drug could not be ruled out."
Four years later the AstraZeneca sales rep joined a colleague in meeting with a physician who was complaining of "getting a lot of flak" from patients with regard to reports of diabetes risk.
According to the contents of the sales call notes, the AstraZeneca employee assured the doctor "there has been no causative effect" linking Seroquel and diabetes. As a result of that assurance, the doctor "said he would not quit writing" prescriptions for Seroquel "due to this, at this time," the employee reported in her call notes.
In a similar example, another Seroquel representative reported to his superiors at AstraZeneca in 2005 that he had "discussed weight gain associated with atypicals (the class of drug to which Seroquel belongs)" with a doctor. He went on to report in his notes that he assured the doubting physician of a low incidence of weight gain amongst Seroquel users and encouraged the doctor to make Seroquel his "first line choice."

Seroquel Side Effects Pooh-Poohed

Another revelation surfaced earlier when other documents were unsealed. 
According to Bloomberg, AstraZeneca coached its sales force in the art of deflecting questions about weight gain associated with Seroquel. One AstraZeneca manager, in a 2005 voicemail, offered the US sales force information they could employ to "neutralize customer objections to Seroquel's weight and diabetes profile."
According to Bloomberg the potential for diabetes and weight gain had been observed in some clinical trials—thus the concern was known at the time Seroquel was approved in 1997. Evidence suggests that AstraZeneca attempted to downplay that risk. While the manufacturer warned doctors in Japan over the importance of monitoring blood-sugar levels in 2002, that same warning wasn't made to US doctors until two years later.

#AstraZeneca #Seroquel #Rischi #Diabete #CauseLegali

Seroquel di AstraZeneca, 26000 Azioni Legali

#AstraZeneca #Seroquel #Diabete #FDA #CauseLegali 

Zyprexa collegato a diabete, iperglicemia

Zyprexa linked to Diabetes, Hyperglycemia

Zyprexa (olanzapine), prescribed for the treatment of schizophrenia and bipolar mania, has been linked to serious side effects. These Zyprexa side effects reportedly include diabetes mellitus, hyperglycemia, pancreatitis and increased risk of suicide. According to some lawsuits, Eli Lilly, maker of Zyprexa, allegedly knew about the link between Zyprexa and diabetes but failed to adequately warn the public about that risk. 

Zyprexa Diabetes and Hyperglycemia

Eli Lilly & Co. is accused of heavily promoting Zyprexa as a safe and effective drug for psychotic disorders, while virtually concealing the risks of side effects from doctors and from the patients themselves. In a recent lawsuit, the courts agreed with lawyers representing consumers, finding that prior to 2003, Eli Lilly did not properly disclose risks and known side effects of Zyprexa. 
With worldwide distribution to thousands of consumers, Zyprexa's side effects were considered such a risk that in 2002, both the Japanese Health and Welfare Ministry and the Great Britain Medicines Control Agency issued emergency warnings concerning Zyprexa and diabetes-related complications. 
According to The New York Times (January 5, 2007), in 2007, Eli Lilly agreed to pay up to $500 million to settle 18,000 lawsuits alleging patients developed diabetes or other serious side effects after taking Zyprexa. By early 2007, according to the newspaper, Lilly had agreed to pay at least $1.2 billion to approximately 28,500 people who alleged the use of Zyprexa caused them harm. 
The Food and Drug Administration (FDA) issued a warning label in 2003 for all atypical anti-psychotic drugs to include the risk of hyperglycemia. Currently, Zyprexa is still approved as safe and effective. Patients should be aware that it could be dangerous to stop taking the medication, especially abruptly, and should talk with their physicians to decide whether the benefits outweigh the risks of taking Zyprexa. 

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#Zyprexa #Olanzapina #Diabete #Pancreatiti #CauseLegali

Abilify ed effetti collaterali

Abilify Side Effects
Last updated on Aug-19-2011

Abilify (known generically as aripiprazole) is in a class of drugs called atypical antipsychotics and is used to treat schizophrenia. Abilify side effects reportedly include an increased risk of diabetes and other blood sugar disorders, including hyperglycemia. Other aripiprazole side effects could include tremors and uncontrollable movements. 

Abilify Aripiprazole
darvondarvocetpillstackart Abilify is an atypical antipsychotic that is used to treat schizophrenia, bipolar disorder, major depressive disorder and irritability associated with autistic disorder. Antipsychotic medications have reportedly been linked to serious side effects including an increased risk of diabetes and other blood sugar disorders. They are also linked to a risk of harm to newborns. 

Abilify and Pregnancy

The US Food and Drug Administration issued a warning in February 2011 alerting patients to a risk of harm to a newborn when women who are pregnant or planning on becoming take medications such as Abilify. According to the warning, the medications could cause abnormal muscle movements and withdrawal symptoms when the infants were exposed to the medications during the third trimester. 

Aripiprazole Side Effects
According to the medication guide, elderly patients with dementia-related psychosis may be at an increased risk of death when taking Abilify. In 2008, the FDA requested that antipsychotic drugs, including Abilify, update their warnings to include the increased risk of death when Abilify is used to treat dementia in older patients. Furthermore, young patients with depression who take Abilify may be at an increased risk of suicidal thoughts or actions. 

Patients who take atypical antipsychotic medications may also be at an increased risk of developing hyperglycemia or diabetes. A 2009 study published in Psychopharmacology Bulletin found that patients taking an atypical antipsychotic medication were at a higher risk for developing diabetes. Researchers recommended that patients taking an antipsychotic medication be monitored for diabetes. 

Abilify and Veterans
A study published in The Journal of the American Medical Association suggests that antipsychotic medications such as Abilify may be no more effective than placebos at treating severe post-traumatic stress symptoms and may come with serious side effects. According to an article in The New York Times (08/02/11), the study focused on Risperdal but the results could extend to other drugs in the same class, including Seroquel and Abilify. 
Researchers found that patients who were given Risperdal to treat post-traumatic stress had the same rate of recovery—approximately five percent—as those treated with a placebo. Between 10 and 20 percent of patients in both groups reported some improvement. The concern is that patients might not receive any benefit from taking the antipsychotic medications but are still being put at risk of serious side effects. 

Abilify patients in California and across the US do not necessarily have to have suffered Abilify side effects to speak to a lawyer. If you used Abilify and it did not work for you, speak to a lawyer about your legal options. 
#Abilify #Aripiprazole #Gravidanza #EffettiCollaterali #Veterani

AstraZeneca potrebbe affrontare 6000 cause legali per gli effetti collaterali di Seroquel

AstraZeneca Could Face 6,000 Lawsuits over Seroquel Side Effects

December 6, 2009

Orlando, FL: A recent ruling from a U.S. district judge could create approximately 6000 individual trials for British drug maker AstraZeneca, which faces litigation over Seroquel Side Effects.
Anne Conway, the judge overseeing the preliminary proceedings in the federal Seroquel trial, has recommended returning all individual cases related to the antipsychotic medication back to local courts.
"(This decision) will get the litigation moving," said Paul Pennock, a lawyer for former Seroquel users, in an interview with Bloomberg. "The decision will help get a huge group of cases to a state of trial-worthiness."
Seroquel has been linked to serious side effects, incuding increased risk of diabetes, hyperglycemia, neuroleptic malignant syndrome, tardive dyskinesia and uncontrollable movements.
Seroquel reportedly sold $4.45 billion last year, despite the more than 14,000 lawsuits it faces in the US relating to diabetes claims.

Judge Conway has ordered Astra to meet with a mediator to explore settlement options for the wealth of cases the pharmaceutical giant is facing.
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#Seroquel #Quetiapine #Diabete #SNM #DiscinesiaTardiva

Seroquel e diabete; email interne rivelano che AstraZeneca sapeva

Seroquel Data on Diabetes Buried

Unsealed Emails from AstraZeneca Reveal Cover-Up

An internal email from AstraZeneca (AZ) about its controversial a-typical antidepressant Seroquel, marketed as Quietiapine, allegedly shows that the company knew the drug could cause diabetes. According to one of the lawyers on the case, AZ not only deliberately avoided warning physicians about the risk for diabetes connected with the anti-depressant, but also marketed the drug as virtually 'risk free.'
The email, released as part of a court case against the drug maker, and covered in the media last week, allegedly praised the Seroquel project doctor, Lisa Arventis, for minimizing data from a study which showed that the drug caused diabetes, stating "Lisa has done a great 'smoke and mirrors job!'
The message is just one of 102 documents unsealed during the trial. Reportedly, another of these emails, from the company's publications manager written in 1999, reads "The larger issue is how do we face the outside world when they begin to criticize us for suppressing data." Allegedly, he goes on to say that data from 3 drug trials had been "buried." And, in referencing a fourth trial, says, "We must find a way to diminish the negative findings. But, in my opinion, we cannot hide them."
Seroquel is FDA approved for the treatment of schizophrenia, and bipolar disorder, but is also prescribed "off-label" for depression, insomnia, dementia, and ADHD.
March-02-2009: Drug Maker's E-Mail Released in Seroquel Lawsuit 
[NY TIMES: DRUG MAKER'S EMAIL RELEASED IN SEROQUEL LAWSUIT ]

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#Seroquel #Quetiapine #Diabete #ADHD #Depressione #FDA

Seroquel, 17500 Cause Legali per 198 Millioni di Dollari

17,500 Seroquel Suits Settled for $198 Million

London, UK: Astra Zeneca (AZ), the maker of the antipsychotic medication, Seroquel, has settled 17,500 US-based personal injury claims for $198 million. The suits claim illnesses such as diabetes related to the drug, which is used to treat schizophrenia and bipolar disorder. According to a report on Reuters, the average settlement per claim is $11,300. 

These settlements follow on from several thousand claims settled in early August. 

A further 2,900 cases were dismissed. 


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Last updated on Aug-9-2010

#AstraZeneca #Seroquel #Quetiapine #Diabete #CauseLegali #ClassAction

AstraZeneca, Seroquel, 4000 Cause Legali per diabete

AZ Tentatively Settles 4,000 Seroquel Suits

Wilmington, Delaware: AstraZeneca (AZ) has reportedly tentatively settled a further 4,000 lawsuits brought by people who allege the company's antipsychotic medication Seroquel, causes diabetes.

The terms of the settlements will be kept confidential. However, the company recently settled 200 similar suits for $2 million putting the average settlement at $10,000 per case.

AZ was facing more than 10,000 related suits involving some 22,500 plaintiff groups. The company reportedly said it has spent about $688 million defending Seroquel-related cases to date.


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Last updated on Aug-4-2010

#AstraZeneca #Seroquel #Quetiapine #Diabete #CauseLegali #ClassAction

AstraZeneca, Seroquel Cause Legali

AstraZeneca Settles More Seroquel Suits

London, UK: AstraZeneca, the maker of antipsychotic drug Seroquel, has agreed to pay $150 million to settle more lawsuits that allege the drug causes diabetes.

This latest settlement should conclude some 6,000 lawsuits, each of which will reportedly be settled for roughly $25,000 a piece.

According to a report on Bloomberg, this court-ordered settlement leaves AstraZeneca facing about 4,000 outstanding Seroquel claims. Last summer the UK-based pharmaceutical company said it had resolved about two-thirds of the 26,000 suits over the drug that had been filed in courts around the U.S.


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Last updated on Feb-17-2011

#AstraZeneca #Seroquel #Quetiapine #CauseLegali #ClassAction

AstraZeneca, Seroquel collegato a diabete, Class Action

Seroquel

September-2-2003

A class action lawsuit has been filed against AstraZeneca PLC on behalf of all patients who have used the anti-psychotic drug Seroquel. The suit was filed in regards to a study which was recently released and linked the use of Seroquel to an unacceptable rate of diabetes onset. The suit alleges that the company was aware that use of Seroquel could cause a high occurrence of diabetes; however they failed to adequately warn doctors or patients in the United States. The suit further claims that although the versions of Seroquel sold in Japan are accompanied with a warning label, this safer, more accurate and comprehensive label has not been used in the US. The suit also alleges that AstraZeneca engaged in marketing and promoting Seroquel for off label use that was beyond its FDA approved indications.

If you feel you qualify for damages or remedies that might be awarded in this class action please fill in the form to the right to submit your complaint.

#AstraZeneca #Seroquel #ClassAction #CauseLegali #FDA

AstraZeneca, Seroquel antipsicotico causa diabete

AZ Settles 200 Seroquel Suits for $2 Million

New York, NY: AstraZeneca, makers of the antipsychotic medication Seroquel, have agreed to pay $2 million to settle over 200 cases alleging the medicine causes diabetes. The settlement could mean an average payment per case of $10,000. 

The settlement is the result of a US-court ordered mediation involving some 26,000 cases filed in the UK against the London-based pharmaceutical company.

AZ won the first Seroquel lawsuit to go to trial, when a jury in New Jersey ruled that the company had properly warned the patient's doctor about the risk for diabetes associated with the drug. And a further three Seroquel cases have been thrown out because the plaintiffs were unable to provide enough credible evidence to support their claims of Seroquel-generated diabetes. 

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Last updated on Jul-23-2010
#AstraZeneca #Seroquel #Quetiapine #Diabete #CauseLegali #ClassAction

Janssen, Risperdal [Risperidone], Diabete e Malattie cardiache

#Janssen #Risperdal #Risperidone #EliLilly #Zyprexa #Antipsicotici #Diabete
 #Ictus #MalattieCardiache #AttacchiDiCuore #MalattieCardiovascolari

Risperdal [Risperidone] Cause Legali [Autismo, Sindrome Bipolare, Schizofrenia]

#Janssen #Risperdal #Risperidone #Autismo #ADHD #DiscinesiaTardiva
#Diabete #Ictus #Morte #OffLabel

Zyprexa, Canada, Class Action, Eli Lilly

#Zyprexa #Olanzapina #Canada #ClassAction #Lawsuit #EliLilly #diabete #pancreatiti
#chetoacidosi #Ontario #OffLabel #Antipsicotici 

Seroquel, Cause Legali, Effetti Collaterali, Problemi di Peso e Obesità, AstraZeneca, Diabete, Farmaci, Frode

Ancora cause legali per Seroquel e AstraZeneca. Seroquel ed effetti collaterali. Seroquel e diabete.
#Seroquel #AstraZeneca #CauseLegali #diabete #AumentoDiPeso #Iperglicemia
#DiscinesiaTardiva #SindromeNeuroletticaMaligna

Eli Lilly, Zyprexa, Cause Legali, Cadute, Fratture, Diabete, Frode, Class Action, Suicidi

Zyprexa: Eli Lilly paga 15 milioni di dollari in una causa legale. Zyprexa: collegato a fratture negli anziani. 
Zyprexa: collegato a diabete. Eli Lilly : class action per frode. Zyprexa: associato a comportamenti suicidi.
E la vicenda Eli Lilly e Zyprexa continua... ...e continuano le vittime...
#EliLilly, #Settlement, #Zyprexa, #Lawsuit, #Falls, #Fractures, #Diabetes, #Fraud, #ClassAction, #Suicides