Zyprexa e Suicidi: Bambini a Rischio

Zyprexa Suicide: Children at Risk

January 15, 2008

Fayetteville, TN

When Sarah D. was only a child she was put on Zyprexa to help control the mood swings associated with her bipolar disorder. Beth (Sarah's mother) says that they tried several drugs, but from around age eight to age fourteen, Sarah took Zyprexa. According to both Beth and Sarah, it was only a matter of months after her prescription began before Sarah started cutting herself.
"When she was on Zyprexa, she exhibited suicidal tendencies," Beth says. "She talked in a very degrading manner about herself and tried cutting herself. It was really strong when she was an adolescent. She would draw pictures of her cutting herself, taking pills, running in front of a car or hanging herself. She even said it would be all she could do not to run in front of a car when she was next to traffic.

"She would cut herself and hide the cuts. I had to hide the knives from her. She never had to be hospitalized—it never got that far. But she would talk about how suicidal she was, so it was still fairly serious.
"Her dad and I could not understand why—she is a beautiful daughter—why all of a sudden she was feeling terrible about herself. Her self-esteem plummeted. She was fixated with cutting herself. And she would use other things, not just knives. Pencils, ink pens, nail cutters...anything. She started having bizarre behaviors like crawling under tables and desks at school. She would dig into the door and furniture and carve things like, 'I hate myself,' or 'I'm gonna kill myself,' or 'die, die, die,' and then cover them with posters. I only found out about that when a poster fell off the door. But they didn't take her off Zyprexa.
"Now, she looks back and realizes that she doesn't know where those behaviors came from."
Sarah (now 16 years old) says that she remembers some of her time on Zyprexa, but not all of it. "I felt depressed a lot of the time," Sarah says. "I didn't like taking it. It made me so bad and I didn't like feeling bad. I had low self-esteem. That has changed since I stopped taking it. My esteem has gone way up. I was happy to stop taking it."
She says that she cut her arms almost every day, but does not know what she was thinking when she did. "My mind was rambling, I don't know what was going through my head. It affected how I thought—I couldn't think straight most of the time I was on it."

READ MORE LEGAL NEWS

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• Zyprexa: Suicide can be a Side Effect of Drugs

Both Beth and Sarah agree that Sarah's behavior took a turn for the worse only a few months after she started taking Zyprexa. She has now been off Zyprexa for two years and in that time has stopped cutting herself and no longer experiences suicidal tendencies.
"We want to trust doctors and when they recommend something, we want to listen to what they say," Beth says. "We want to help our children, but that was a nightmare. Zyprexa was a nightmare. You wonder if that suicidal cutting could have been avoided."
Like many other people, Beth wants to see Eli Lilly pay for the harm she believes Zyprexa has caused. "I am going to follow up with this," Beth says. "I'm convinced it was that drug. I don't think she would have acted like that if she hadn't been on Zyprexa."

 

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#Zyprexa #Olanzapina #Suicidio #Bambini #EliLilly 

Zyprexa, Abilify, Risperdal e Seroquel collegati a Rapido Aumento di Peso nei Bambini

Zyprexa, Abilify, Risperdal, and Seroquel Linked to Rapid Weight Gain in Children

October 29, 2009

Washington, DCThe largest study of its kind to show an association between atypical antipsychotics such as Zyprexa, and rapid weight gain and metabolic changes that can lead to diabetes and hypertension was published Wednesday in the Journal of the American Medical Association (JAMA). The study was conducted in 272 children aged between 4 and 19 years. 

Study investigators evaluated the four top selling antipsychotic medications used in the treatment of schizophrenia and bipolar disorder, namely Zyprexa (Eli Lilly & Co); Abilify, (Bristol-Myers Squibb Co and Otsuka Pharmaceutical Co); Risperdal (Johnson & Johnson); and Seroquel ( AstraZeneca PLC).
Of the four atypical antipsychotics, Zyprexa caused the most weight gain over the course of the study – at nearly 19 lbs, a 15 percent increase. Importantly, Zyprexa was also found to significantly raise cholesterol, insulin, triglycerides and blood sugar levels, all of which can lead to the development of diabetes and heart disease.
Children taking Abilify, Risperdal, and Seroquel gained an average of between 10 and 13 pounds over the 11 weeks, and the drugs' impact on metabolic disease indicators varied.
In an article published in the Wall Street Journal (wsj.com), Christoph Correll, the study's lead author and a psychiatrist and scientist at the Feinstein Institute for Medical Research in Manhasset, NY, said, "The weight gain is much larger than we thought. It's massive, and it's the medication that caused it."

 

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#Zyprexa #Abilify #Risperdal #Seroquel #Obesità #Bambini 

#Diabete #Ipetensione #JAMA #WSJ

Studio: farmaci come Abilify potrebbero non aiutare con lo stress

Study: Drugs Like Abilify May Not Help with Stress

August 27, 2011

Washington, DC
A new study suggests that drugs like Abilify may not be effective in dealing with severe stress. Furthermore because of the risk of Abilify side effects, these drugs may be more risky for patients than necessary. Concerns about Abilify side effects include problems with Abilify for children and concern about problems with Abilify and pregnancy.
The study, which was reported in The New York Times (08/02/11), suggests that drugs used to treat severe post-traumatic stress symptoms have approximately the same effectiveness as placebos but also carry serious side effects. Published in The Journal of the American Medical Association, the study examined the use of Risperdal to treat veterans with post-traumatic stress symptoms. Risperdal, an antipsychotic medication, is in the same class of drugs as Abilify and Seroquel, leading experts to conclude that the same results could be found of Abilify.

Researchers found that veterans who were given Risperdal to treat post-traumatic stress had a similar recovery rate as those who were given a placebo. After six months of treatment, approximately five percent of veterans in both groups recovered and between 10 and 20 percent had some improvement, but had not fully recovered. This led researchers to conclude that treatment with the medication did not have an overall benefit for the veterans.
In February 2011, the US Food and Drug Administration (FDA) issued a warning about the use of Abilify during pregnancy. According to the warning, use of Abilify while pregnant could cause abnormal muscle movements and withdrawal in infants exposed to the medications prior to birth. Symptoms of these conditions include agitation, abnormal muscle tone, tremors and severe difficulty breathing.
The FDA noted that a search of the Adverse Event Reporting System (AERS) through October 29, 2008, found 69 cases of neonatal events, including abnormal muscle movements or withdrawal with all antipsychotic drugs. The agency reported that it was not known if the cause of the events were drug toxicity or drug withdrawal. Onset of symptoms ranged from birth to one month after birth. According to the FDA, some infants recovered on their own, while others required intensive care and prolonged hospitalization.

Women who take Abilify and are pregnant or planning on becoming pregnant should discuss their options with their doctor.
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#Abilify #Aripiprazole #Gravidanza #Veterani #Rischi